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Literature summary extracted from

  • Fink, E.; Bhoola, K.D.; Snyman, C.; Neth, P.; Figueroa, C.D.
    Cellular expression of plasma prekallikrein in human tissues (2007), Biol. Chem., 388, 957-963.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.34 extracellular kallikrein Homo sapiens
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-
3.4.21.34 intracellular prekallikrein Homo sapiens 5622
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.34 additional information Homo sapiens kallikrein participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation, it has different specific cellular functions dependent on the tissue, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.34 Homo sapiens P03952
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.34 proteolytic modification prekallikrein is synthesized in hepatocytes and other cell types and secreted to the blood, and proteolytically activated to kallikrein Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.34 breast synthesis of prekallikrein Homo sapiens
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3.4.21.34 kidney single cells of the distal tubules, synthesis of prekallikrein Homo sapiens
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3.4.21.34 Langerhans cell synthesis of prekallikrein Homo sapiens
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3.4.21.34 Leydig cell synthesis of prekallikrein Homo sapiens
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3.4.21.34 liver plasma prekallikrein is synthesised in hepatocytes and epithalial liver cells, and secreted into the blood Homo sapiens
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3.4.21.34 oesophagus synthesis of prekallikrein Homo sapiens
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3.4.21.34 ovary follicular and thecal granulosa cells Homo sapiens
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3.4.21.34 parotid gland synthesis of prekallikrein Homo sapiens
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3.4.21.34 plasma kallikrein Homo sapiens
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3.4.21.34 prostate synthesis of prekallikrein Homo sapiens
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3.4.21.34 respiratory tract synthesis of prekallikrein Homo sapiens
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3.4.21.34 skin synthesis of prekallikrein Homo sapiens
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3.4.21.34 testis interstitial Leydig cells of the testes, synthesis of prekallikrein Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.34 additional information kallikrein participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation, it has different specific cellular functions dependent on the tissue, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.34 PPK
-
 Homo sapiens